Features of distribution of intratumoral lymphocytes in ovarian epithelial tumours of different histological types and degree of malignancy

Ovarian cancer is the leading cause of death from gynaecological cancers worldwide. In Georgia, ovarian ranks fourth in terms prevalence, and third mortality rate. According to latest epidemiological data, there will be 21,421 new cases 13,770 deaths United States 2021. Due lack early screening methods asymptomatic clinical courses, most diagnosed at an advanced stage, when prognosis disease already poor. Despite advances modern medical treatment surgery, carcinoma remains lethal cancer. The 5-year survival rate 46% for all stages combined. microenvironment carcinomas mainly represented by macrophages, dendritic cells, neutrophils lymphocytes. Epithelial carcinoma-infiltrating lymphocytes (TIL) have attracted much interest last five years. a heterogeneous concerning tumour-infiltrating TILs. histological subtypes, studies include only high-grade serous ovary, on other types are scarce. results our study show that quantitative evaluation T their subpopulations does not statistically reliable correlation between different tumours, which may due intratumoral heterogeneity individual specificity tumours.